The FMR1 Premutation and Attention-Deficit Hyperactivity Disorder (ADHD): Evidence for a Complex Inheritance
| Autor: | Ann Abramowitz, Stephanie L. Sherman, Michael P. Epstein, Stuart W. Tinker, Jessica Ezzell Hunter |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Heterozygote medicine.medical_specialty Adolescent Context (language use) Pedigree chart Risk Assessment behavioral disciplines and activities Article Fragile X Mental Retardation Protein Young Adult Rating scale Surveys and Questionnaires mental disorders Genetics medicine Humans Attention deficit hyperactivity disorder Family Psychiatry Genetics (clinical) Ecology Evolution Behavior and Systematics Family aggregation Middle Aged medicine.disease FMR1 Fragile X syndrome Socioeconomic Factors Attention Deficit Disorder with Hyperactivity Polygene Mutation Linear Models Educational Status Female Psychology Algorithms |
| Zdroj: | Behavior Genetics. 42:415-422 |
| ISSN: | 1573-3297 0001-8244 |
| DOI: | 10.1007/s10519-011-9520-z |
| Popis: | We recently reported elevated symptoms associated with attention-deficit hyperactivity disorder (ADHD) among adult female carriers of the FMR1 premutation. To gain insight into the contribution of this mutation in the context of polygenes, we examined the proportion of variation in these symptoms due to residual genetic factors after adjustment for the effect of the premutation. To accomplish this, we performed a familial aggregation analysis of ADHD symptoms among 231 females from 82 pedigrees using scores from the Connors Adult ADHD Rating Scales. Results indicate that after accounting for the effect of FMR1, there are significant residual polygenic effects on self-reported symptoms of ADHD, as measured by the ADHD Index (p = 0.0117) and problems with self-concept (p = 0.0110), one specific symptom domain associated with ADHD. For both measures, FMR1 accounts for ~5% of the variance while polygenes account for ~50% of the residual variance, suggesting that the premutation acts in concert with additional genetic loci to influence the severity of ADHD symptoms. |
| Databáze: | OpenAIRE |
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