Duality of 5-HT Effects on Crayfish Motoneurons
| Autor: | Daniel Cattaert, Julien Bacqué-Cazenave, Jean-Paul Delbecque, Pascal Fossat, Donald H. Edwards, Fadi A. Issa |
|---|---|
| Přispěvatelé: | Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Tribologie et Dynamique des Systèmes (LTDS), École Centrale de Lyon (ECL), Université de Lyon-Université de Lyon-École Nationale des Travaux Publics de l'État (ENTPE)-Ecole Nationale d'Ingénieurs de Saint Etienne-Centre National de la Recherche Scientifique (CNRS), Nuffield Department of Surgical Sciences [Oxford, UK], University of Oxford [Oxford], Laboratoire de neurobiologie des réseaux (LNR), Université Sciences et Technologies - Bordeaux 1-Centre National de la Recherche Scientifique (CNRS) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
030110 physiology
0301 basic medicine Nervous system serotoninergic neuron Physiology [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology Biology Inhibitory postsynaptic potential lcsh:Physiology 03 medical and health sciences 0302 clinical medicine Physiology (medical) excitatory and inhibitory balance medicine Receptor motoneuron 5-HT receptor ComputingMilieux_MISCELLANEOUS Original Research lcsh:QP1-981 Aggression Crayfish locomotor network serotonin medicine.anatomical_structure sensori-motor interactions Excitatory postsynaptic potential Serotonin crayfish (Procambarus clarkii) medicine.symptom Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Physiology Frontiers in Physiology, Frontiers, 2019, 10, ⟨10.3389/fphys.2019.01280⟩ Frontiers in Physiology, Vol 10 (2019) |
| ISSN: | 1664-042X |
| Popis: | Serotonin (5-HT) is a major neuromodulator acting on the nervous system. Its various effects have been studied in vertebrates, as well as in arthropods, from the cellular and subcellular compartments up to the behavioral level, which includes the control of mood, aggression, locomotion, and anxiety. The diversity of responses of neurons to 5-HT has been related to its mode of application, the diversity of 5-HT-receptors, and the animals’ social status history. In the locomotor network of socially isolated crayfish, the duality of 5-HT-evoked responses (excitatory/inhibitory) on motoneurons (MNs), sensorimotor pathways, and their consequences on motor network activity has largely been studied. The aim of the present report is to examine if this duality of exogenous 5-HT-evoked responses in the crayfish locomotor network can be reproduced by direct activation of 5-HT neurons in the case of socially isolated animals. Our previous studies have focused on the mechanisms supporting these opposite effects on MNs, pointing out spatial segregation of 5-HT receptors responsible either for positive or negative responses. Here, we report new findings indicating that excitatory and inhibitory effects can be achieved simultaneously in different leg MNs by the activation of a single 5-HT cell in the first abdominal ganglion. |
| Databáze: | OpenAIRE |
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