Multispectral, non-contact diffuse optical tomography of healthy human finger joints
| Autor: | Daniel Lighter, Andrew Filer, Jim Hughes, Iain B. Styles, Hamid Dehghani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
musculoskeletal diseases
Multispectral image 01 natural sciences Article 010309 optics 03 medical and health sciences Joint disease 0302 clinical medicine ocis:(170.6510) Spectroscopy tissue diagnostics 0103 physical sciences Medicine Oxygen saturation (medicine) 030203 arthritis & rheumatology medicine.diagnostic_test business.industry ocis:(170.6960) Tomography Magnetic resonance imaging Biological tissue medicine.disease Atomic and Molecular Physics and Optics Diffuse optical imaging 3. Good health Light intensity Rheumatoid arthritis business Biotechnology Biomedical engineering |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| Popis: | Rheumatoid arthritis (RA) is an inflammatory joint disease often affecting the hands, which if untreated causes disability. Diffuse optical tomography (DOT) provides information about the underlying functional properties of biological tissue. To detect pathophysiological changes in inflamed RA joints, a good understanding of the baseline values for healthy subjects is first required. Finger joints from healthy subjects were imaged using a non-contact, multispectral, continuous wave DOT system, recovering physiological parameters of oxygen saturation, total haemoglobin, water concentration and scatter amplitude. Reconstructed values across the cohort demonstrated good consistency between finger joints from the same participant, with greater variation seen between subjects. |
| Databáze: | OpenAIRE |
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