Natural Products and Their Derivatives against Human Herpesvirus Infection
| Autor: | Si-Min Wang, Man Yuan, Hong-Xi Xu, Wenwei Fu, Chattarin Ruchawapol |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
herpesviruses
anti-herpes virus activity DNA polymerase Pharmaceutical Science Review Drug resistance alkaloids Antiviral Agents Analytical Chemistry anthraquinones chemistry.chemical_compound QD241-441 terpenoids Drug Resistance Viral Drug Discovery Anthraquinones medicine Animals Humans Physical and Theoretical Chemistry Herpesviridae polyphenols anthracyclines Biological Products biology Nucleoside analogue Organic Chemistry Herpesviridae Infections Virology Terpenoid Antiherpetic Agents chemistry Chemistry (miscellaneous) flavonoids biology.protein Molecular Medicine Thymidine Human herpesvirus medicine.drug |
| Zdroj: | Molecules, Vol 26, Iss 6290, p 6290 (2021) Molecules |
| ISSN: | 1420-3049 |
| Popis: | Herpesviruses establish long-term latent infection for the life of the host and are known to cause numerous diseases. The prevalence of viral infection is significantly increased and causes a worldwide challenge in terms of health issues due to drug resistance. Prolonged treatment with conventional antiviral drugs is more likely to develop drug-resistant strains due to mutations of thymidine nucleoside kinase or DNA polymerase. Hence, the development of alternative treatments is clearly required. Natural products and their derivatives have played a significant role in treating herpesvirus infection rather than nucleoside analogs in drug-resistant strains with minimal undesirable effects and different mechanisms of action. Numerous plants, animals, fungi, and bacteria-derived compounds have been proved to be efficient and safe for treating human herpesvirus infection. This review covers the natural antiherpetic agents with the chemical structural class of alkaloids, flavonoids, terpenoids, polyphenols, anthraquinones, anthracyclines, and miscellaneous compounds, and their antiviral mechanisms have been summarized. This review would be helpful to get a better grasp of anti-herpesvirus activity of natural products and their derivatives, and to evaluate the feasibility of natural compounds as an alternative therapy against herpesvirus infections in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|