Age- related effects of ischemia, lidocaine and verapamil on overdrive- induced suppression of ventricular pacemakers in isolated rat heart
| Autor: | R. Balbi, F. Rengo, Dario Leosco, P. Landino, P. Caccese, P. Abete, S. Sedcrino, Nicola Ferrara |
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| Přispěvatelé: | Abete, Pasquale, Ferrara, Nicola, Leosco, Dario, Caccese, P, Landino, P, Sederino, S, Balbi, R, Rengo, F., Abete, P |
| Rok vydání: | 1992 |
| Předmět: |
Male
Aging medicine.medical_specialty Lidocaine Ventricular automaticity Ischemia Coronary Disease In Vitro Techniques Basal (phylogenetics) Internal medicine Age related medicine Animals Ventricular Function cardiovascular diseases business.industry Rats Inbred Strains Rat heart medicine.disease Rats Endocrinology medicine.anatomical_structure Verapamil Ventricle cardiovascular system Cardiology Geriatrics and Gerontology business medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1720-8319 1594-0667 |
| DOI: | 10.1007/bf03324085 |
| Popis: | The effect of age on ventricular automaticity in the isolated perfused rat heart was determined under different conditions. When the ventricle is electrically stimulated at a faster rate, drive cessation is followed by a temporary suppression of ventricular automaticity (overdrive suppression). The effects of ischemia, lidocaine and verapamil on overdrive suppression were studied in isolated perfused adult and senescent rat hearts with complete atrio-ventricular block, by monitoring ventricular escape rate and escape rhythm recovery time after 1 minute of overdrive at a constant multiple (x3) of the spontaneous rate. The results demonstrated that: 1) lidocaine decreases ventricular automaticity especially in senescent hearts; 2) verapamil does not modify ventricular automaticity in basal conditions in either adult or senescent hearts; 3) myocardial ischemia causes a reduction in ventricular automaticity and more markedly in senescent hearts; and 4) lidocaine exaggerates the effect of ischemia, while verapamil seems to antagonize its depressant effect more in adult than in senescent hearts. |
| Databáze: | OpenAIRE |
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