Head-to-Tail Cyclization after Interaction with Trypsin: A Scorpion Venom Peptide that Resembles Plant Cyclotides
| Autor: | Lourival D. Possani, Sonia Maria de Freitas, Rita Restano-Cassulini, João Alexandre Ribeiro Gonçalves Barbosa, Maura V. Prates, Caroline Barbosa Farias Mourão, Carlos Bloch, João Paulo Campos Fernandes, Guilherme D. Brand, Elisabeth F. Schwartz |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Molecular Protein Conformation Trypsin inhibitor Peptidase Inhibitors Scorpion Scorpion Venoms Cyclotides Peptide Venom CHO Cells complex mixtures Cricetulus biology.animal Drug Discovery medicine Animals Trypsin Amino Acid Sequence chemistry.chemical_classification biology Tityus obscurus chemistry Biochemistry Cyclization Molecular Medicine Protein Binding medicine.drug |
| Zdroj: | Journal of Medicinal Chemistry. 63:9500-9511 |
| ISSN: | 1520-4804 0022-2623 |
| Popis: | Peptidase inhibitors (PIs) have been broadly studied due to their wide therapeutic potential for human diseases. A potent trypsin inhibitor from Tityus obscurus scorpion venom was characterized and... |
| Databáze: | OpenAIRE |
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