Plasma Free Fatty Acids Metabolic Profile with LC-MS and Appetite-Related Hormones in South Asian and White European Men in Relation to Adiposity, Physical Activity and Cardiorespiratory Fitness: A Cross-Sectional Study
| Autor: | Natasha J. Hill, Judith Allgrove, Declan P. Naughton, Hannah Moir, Mansour A. Alzharani, Simone Benedetti, Naser F. Al-Tannak, David J. Stensel, Alice E. Thackray, David G. Watson, Mehmet Tevfik Dorak, Owen Spendiff |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
RM
medicine.medical_specialty Endocrinology Diabetes and Metabolism media_common.quotation_subject lcsh:QR1-502 physical activity alliedhealth 030209 endocrinology & metabolism Type 2 diabetes 030204 cardiovascular system & hematology Biochemistry Body fat percentage Article lcsh:Microbiology 03 medical and health sciences 0302 clinical medicine cardiovascular disease Internal medicine metabolic markers medicine South Asian Molecular Biology media_common cardiorespiratory fitness business.industry Leptin Cardiorespiratory fitness Appetite free fatty acids medicine.disease metabolomics Endocrinology inflammation Peptide YY appetite hormones lipids (amino acids peptides and proteins) Ghrelin sports business Hormone |
| Zdroj: | Metabolites, Vol 9, Iss 4, p 71 (2019) Metabolites Volume 9 Issue 4 |
| ISSN: | 2218-1989 |
| Popis: | South Asians have a greater cardiovascular disease (CVD) and type 2 diabetes (T2D) risk than white Europeans, but the mechanisms are poorly understood. This study examined ethnic differences in free fatty acids (FFAs) metabolic profile (assessed using liquid chromatography-mass spectrometry), appetite-related hormones and traditional CVD and T2D risk markers in blood samples collected from 16 South Asian and 16 white European men and explored associations with body composition, objectively-measured physical activity and cardiorespiratory fitness. South Asians exhibited higher concentrations of five FFAs (laurate, myristate, palmitate, linolenic, linoleate p &le 0.040), lower acylated ghrelin (ES = 1.00, p = 0.008) and higher leptin (ES = 1.11, p = 0.004) than white Europeans total peptide YY was similar between groups (p = 0.381). South Asians exhibited elevated fasting insulin, C-reactive protein, interleukin-6, triacylglycerol and ratio of total cholesterol to high-density lipoprotein cholesterol (HDL-C) and lower fasting HDL-C (all ES &ge 0.74, p &le 0.053). Controlling for body fat percentage (assessed using air displacement plethysmography) attenuated these differences. Despite similar habitual moderate-to-vigorous physical activity (ES = 0.18, p = 0.675), V ˙ O2max was lower in South Asians (ES = 1.36, p = 0.001). Circulating FFAs in South Asians were positively correlated with body fat percentage (r2 = 0.92), body mass (r2 = 0.86) and AUC glucose (r2 = 0.89) whereas in white Europeans FFAs were negatively correlated with total step counts (r2 = 0.96). In conclusion, South Asians exhibited a different FFA profile, lower ghrelin, higher leptin, impaired CVD and T2D risk markers and lower cardiorespiratory fitness than white Europeans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|