Recurrent bacterial translocation from gut and sepsis in Head and neck cancer patients and its prevention by probiotics
| Autor: | Shunji Tamagawa, Mehmet Gunduz, Muneki Hotomi, Masanobu Hiraoka, Daichi Murakami, Ihsan Gunduz, Gen Sugita |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty medicine.medical_treatment Chromosomal translocation Antineoplastic Agents Bacterial translocation Gastroenterology law.invention Sepsis 03 medical and health sciences Probiotic 0302 clinical medicine law Internal medicine medicine Humans Intestinal Mucosa Laryngeal Neoplasms Chemotherapy business.industry Probiotics Head and neck cancer Hypopharyngeal cancer General Medicine Middle Aged medicine.disease Intestines Lactobacillus 030104 developmental biology Head and Neck Neoplasms 030220 oncology & carcinogenesis Bacterial Translocation Carcinoma Squamous Cell Bifidobacterium business Chemoradiotherapy |
| Zdroj: | Medical hypotheses. 120 |
| ISSN: | 1532-2777 |
| Popis: | Head and neck cancers are the 6th most common cancer type in human malignant tumors and treated with chemoradiotherapy and surgery. Chemotherapy during these treatment modalities leads to damage of intestinal epithelial barriers and results in translocation of intestinal bacteria in bloodstream through invasion in these damaged regions. In this report, we report two cases of hypopharyngeal cancer patients, both of whom received chemotherapy before surgery. The patients demonstrated repeated sepsis before and after surgery, supporting translocation of intestinal bacteria. Proper continuous probiotic use prevented proliferation and intestinal bacterial translocation. Hypothesis of bacterial translocation and prevention by probiotics are discussed. |
| Databáze: | OpenAIRE |
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