Serum lipid and apolipoprotein profiles in newborns and six‐year‐old children: The Tallinn Young Family Study
Autor: | E. Kurvinen, Jouko Sundvall, Zordania R, Matti Jauhiainen, Katrin Aasvee |
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Rok vydání: | 2005 |
Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Clinical Biochemistry Cardiovascular risk factors Total cholesterol Internal medicine Humans Medicine Child Apolipoprotein e polymorphism Preschool child biology business.industry Infant Newborn nutritional and metabolic diseases General Medicine Lipoprotein(a) Lipids Pedigree Apolipoproteins Phenotype Endocrinology Quartile biology.protein Female lipids (amino acids peptides and proteins) business Follow-Up Studies Lipoprotein |
Zdroj: | Scandinavian Journal of Clinical and Laboratory Investigation. 65:541-550 |
ISSN: | 1502-7686 0036-5513 |
Popis: | Seventy children aged 6 years (34 boys, 36 girls) were studied for cardiovascular risk factors. Among the children 40 had also been investigated at birth. The aim of the study was to determine changes in serum lipoprotein parameters from birth up to preschool age and to assess the role of some relevant factors that might affect the process. An obvious association was found between serum apolipoprotein (apo) B levels, the apoB/apoA-I ratio and lipoprotein(a) (Lp(a)) levels at birth and at 6 years of age (r = 0.43; p0.05, r = 0.73; p0.0001 and r = 0.81; p0.0001, respectively). Thirty percent of children who were in the top quartile by apoB or total cholesterol levels and 66.7% of those in this quartile by apoB/apoA-I ratio at birth remained in the top quartiles also in the follow-up study. The significantly higher apoB/apoA-I ratio in newborns and the apoB/apoA-I and apoB values in the 6-year-old children were observed in the carrier apoE4 isoform as compared to E3 homozygotes. A significant influence of apoE polymorphism on serum apoB/apoA-I ratio and apoB level in preschool children was confirmed by ANOVA one-way analysis of variance. In a multiple regression analysis from all the studied factors, the independent determinants of apoB level in preschool age were apoE phenotype, gestational age and Apgar score in the first minute of life. Thus, tracking of serum Lp(a), apoB, apoB/apoA-I ratio and total cholesterol levels from birth up to 6 years of age was demonstrated. The association between apoE polymorphism and serum lipoprotein parameters became more obvious after the first 6 years of life. |
Databáze: | OpenAIRE |
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