| Autor: |
Hyunjoon Kim, Seung Ho Lee, Adam Wentworth, Sahab Babaee, Kaitlyn Wong, Joy E. Collins, Jacqueline Chu, Keiko Ishida, Johannes Kuosmanen, Joshua Jenkins, Kaitlyn Hess, Aaron Lopes, Joshua Morimoto, Qianqian Wan, Shaunak V. Potdar, Ronan McNally, Caitlynn Tov, Na Yoon Kim, Alison Hayward, Daniel Wollin, Robert Langer, Giovanni Traverso |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Biomaterials. 288:121703 |
| ISSN: |
0142-9612 |
| DOI: |
10.1016/j.biomaterials.2022.121703 |
| Popis: |
Intravesical instillation is an efficient drug delivery route for the local treatment of various urological conditions. Nevertheless, intravesical instillation is associated with several challenges, including pain, urological infection, and frequent clinic visits for catheterization; these difficulties support the need for a simple and easy intravesical drug delivery platform. Here, we propose a novel biodegradable intravesical device capable of long-term, local drug delivery without a retrieval procedure. The intravesical device is composed of drug encapsulating biodegradable polycaprolactone (PCL) microcapsules and connected by a bioabsorbable Polydioxanone (PDS) suture with NdFeB magnets in the end. The device is easily inserted into the bladder and forms a 'ring' shape optimized for maximal mechanical stability as informed by finite element analysis. In this study, inserted devices were retained in a swine model for 4 weeks. Using this device, we evaluated the system's capacity for delivery of lidocaine and resiquimod and demonstrated prolonged drug release. Moreover, a cost-effectiveness analysis supports device implementation compared to the standard of care. Our data support that this device can be a versatile drug delivery platform for urologic medications. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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