Role of rectal formulations: enemas
| Autor: | Andrea Belluzzi, Corrado Brignola, A. Petronelli, Mario Miglioli, Massimo Campieri, Paolo Gionchetti, M. Tampieri, P. Iannone, Luigi Barbara |
|---|---|
| Přispěvatelé: | Campieri M., Gionchetti P., Belluzzi A., Brignola C., Tampieri M., Iannone P., Petronelli A., Miglioli M., Barbara L. |
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Enema Gastroenterology digestive system chemistry.chemical_compound Mesalazine Maintenance therapy Sulfasalazine Internal medicine medicine Mesalazine enema Humans Mesalamine Chemotherapy Ulcerative coliti Extensive Disease business.industry medicine.disease Ulcerative colitis Aminosalicylic Acid digestive system diseases Aminosalicylic Acids surgical procedures operative chemistry Rectal administration Colitis Ulcerative business medicine.drug Human |
| Zdroj: | Scandinavian journal of gastroenterology. Supplement. 172 |
| ISSN: | 0085-5928 |
| Popis: | Clinical experience with mesalazine enemas in the treatment of ulcerative colitis is reviewed. After rectal administration, plasma mesalazine levels remain low, and 15% of the administered dose is recovered in the urine. Enemas containing 2 and 4g of mesalazine have been shown to be effective, safe, and well tolerated by patients with mild and moderate ulcerative colitis. Patients who cannot tolerate sulfasalazine and patients who do not respond to other treatments have been successfully treated with mesalazine enemas. Suppositories of mesalazine are more suitable for patients with disease confined to the distal region of the colon, whereas mesalazine enemas should be used in patients with more extensive disease. Mesalazine enemas have also been used for maintenance therapy in ulcerative colitis. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
| Databáze: | OpenAIRE |
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