Zur Farbreaktion von Amiloridhydrochlorid Ph. Eur
| Autor: | Klaus Görlitzerl, Edith Gößnitzer, Peter G. Jones, Winfried Wendelin, Silke Huth |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2001 |
| Předmět: |
MS analysis
Bromine Chemistry 5-chloro Ms analysis Pharmaceutical Science chemistry.chemical_element Medicinal chemistry Amiloride 3-(3-amino-l 2 4-oxadiazol-5-yl) and NMR analysis NMR spectra database Amiloride Hydrochloride colour reaction with bromine 2 6-Pyrazinediamine medicine Organic chemistry Dehydrogenation X ray analysis X-rayanalysis medicine.drug |
| Zdroj: | Scientia Pharmaceutica Volume 69 Issue 4 Pages 574-586 Pages 275-287 |
| ISSN: | 2218-0532 |
| DOI: | 10.3797/scipharm.aut-01-199 |
| Popis: | The reaction of amiloride hydrochloride (1.HCI) with bromine in alkaline solution generated a yellow-brown dehydrogenation product, which tumed out as 3-(3-amino-I,2,4-oxadiazol-5-yl)-5-chloro-2,6-pyrazinediamine (2). The structure was deduced from the MS and the NMR spectra of 2 with the help of comparisons with corresponding spectra of amiloride (1) and reference substances 3 - 5. The agreement of all relevant data of the product and of authentical oxadiazolylpyrazine 2 as weil as the accomplished X-ray analysis confirmed the postulated structure. The mechanism of the formation of 2 is also discussed. |
| Databáze: | OpenAIRE |
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