Comparison of provider-assessed and patient-reported outcome measures of acute skin toxicity during a Phase III trial of mometasone cream versus placebo during breast radiotherapy: the North Central Cancer Treatment Group (N06C4)
| Autor: | David Schwartz, Richard L. Deming, Patricia C. Griffin, Kelli N. Burger, Jon C. Anders, Jeff A. Sloan, Michelle A. Neben-Wittich, Pamela J. Atherton, James A. Martenson, Charles L. Loprinzi, Robert C. Miller |
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| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
medicine.medical_specialty Erythema Mometasone furoate Breast Neoplasms Placebo Article Outcome Assessment Health Care medicine Humans Radiology Nuclear Medicine and imaging Prospective Studies skin and connective tissue diseases Adverse effect Pregnadienediols Radiation business.industry Communication Pruritus Rash Dermatology Surgery Clinical trial Treatment Outcome Oncology Quality of Life Itching Patient-reported outcome Female Dermatologic Agents medicine.symptom Radiodermatitis business Mometasone Furoate medicine.drug |
| Zdroj: | International journal of radiation oncology, biology, physics. 81(2) |
| ISSN: | 1879-355X |
| Popis: | Purpose Considerable interobserver variability exists among providers and between providers and patients when measuring subjective symptoms. In the recently published Phase III N06C4 trial of mometasone cream vs. placebo to prevent radiation dermatitis, the primary provider–assessed (PA) endpoint, using the Common Toxicity Criteria for Adverse Events (CTCAE), was negative. However, prospectively planned secondary analyses of patient-reported outcomes (PROs), using the Skindex-16 and Skin Toxicity Assessment Tool (STAT), were positive. This study assesses the relationship between PA outcomes and PROs. Methods and Materials Pearson correlation coefficients were calculated to compare the three tools. Statistical correlations were defined as follows: 0.7, strong. Results CTCAE dermatitis moderately correlated with STAT erythema, and CTCAE pruritus strongly correlated with STAT itching. CTCAE pruritus had a moderate correlation with Skindex-16 itching. Comparing the 2 PRO tools, Skindex-16 itching correlated moderately with STAT itching. Skindex-16 burning, hurting, irritation, and persistence all showed the strongest correlation with STAT burning; they showed moderate correlations with STAT itching and tenderness. Conclusions The PRO Skindex-16 correlated well with the PRO portions of STAT, but neither tool correlated well with CTCAE. PROs delineated a wider spectrum of toxicity than PA measures and provided more information on rash, redness, pruritus, and annoyance measures compared with CTCAE findings of rash and pruritus. PROs may provide a more complete measure of patient experience than single-symptom, PA endpoints in clinical trials assessing radiation skin toxicity. |
| Databáze: | OpenAIRE |
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