Steroid-responsive encephalopathy with a peculiar CSF biomarker profile in an 89-year-old man
| Autor: | Markku Päivärinta, Eero Rissanen, Jussi O.T. Sipilä, Jaana Korpela |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry Encephalopathy Disease Steroid responsive medicine.disease Microbiology Gastroenterology ta3124 Autoimmune thyroiditis 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Infectious Diseases Cerebrospinal fluid Internal medicine Csf biomarkers medicine Biomarker (medicine) Parasitology business 030217 neurology & neurosurgery |
| Zdroj: | Oxford Medical Case Reports. 2018 |
| ISSN: | 2053-8855 |
| DOI: | 10.1093/omcr/omy073 |
| Popis: | Being treatable, steroid-responsive encephalopathy associated with autoimmune thyroiditis (SREAT), or Hashimoto's encephalopathy, should be distinguished from untreatable conditions. Our patient was a previously healthy 89-year-old man, who presented with cognitive and balance deterioration over several months. His cerebrospinal fluid (CSF) examination was positive for protein 14-3-3 but no other test suggested Creutzfeldt-Jacob disease. His condition improved markedly, although not fully, with intravenous corticosteroids. In control CSF sampling, protein 14-3-3 was negative but a biomarker signature consistent with Alzheimer's disease was observed. SREAT should be considered also in the very elderly in case of subacute encephalopathy. |
| Databáze: | OpenAIRE |
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