Accelerated Evolution of the Pituitary Adenylate Cyclase-Activating Polypeptide Precursor Gene During Human Origin
| Autor: | Ya-ping Qian, Yin-qiu Wang, Ranajit Chakraborty, Peter A. Underhill, Hong Shi, Su Yang, Hong-Kun Zheng, Cheng-hong Liao, Li Jin, Jun Wang, Alice A. Lin, Bing Su, Luigi Luca Cavalli-Sforza |
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| Rok vydání: | 2005 |
| Předmět: |
Pan troglodytes
Evolution Neuronal signal transduction Sequence analysis Amino Acid Motifs Molecular Sequence Data Adenylate kinase Investigations Biology Polymerase Chain Reaction Evolution Molecular Mice Exon Cognition Genetics Animals Humans Amino Acid Sequence Gene Peptide sequence Phylogeny DNA Primers Neurons chemistry.chemical_classification Sequence Homology Amino Acid Brain DNA Exons Biological Evolution Protein Structure Tertiary Amino acid chemistry Biochemistry Signal transduction hormones hormone substitutes and hormone antagonists Signal Transduction |
| Zdroj: | Wang, Y-Q, Qian, Y-P, Yang, S, Shi, H, Liao, C-H, Zheng, H-K, Wang, J, Lin, A A, Cavalli-Sforza, L L, Underhill, P A, Chakraborty, R, Jin, L & Su, B 2005, ' Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin. ', Genetics, vol. 170, no. 2, pp. 801-6 . https://doi.org/10.1534/genetics.105.040527 |
| ISSN: | 1943-2631 |
| DOI: | 10.1534/genetics.105.040527 |
| Popis: | Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide abundantly expressed in the central nervous system and involved in regulating neurogenesis and neuronal signal transduction. The amino acid sequence of PACAP is extremely conserved across vertebrate species, indicating a strong functional constraint during the course of evolution. However, through comparative sequence analysis, we demonstrated that the PACAP precursor gene underwent an accelerated evolution in the human lineage since the divergence from chimpanzees, and the amino acid substitution rate in humans is at least seven times faster than that in other mammal species resulting from strong Darwinian positive selection. Eleven human-specific amino acid changes were identified in the PACAP precursors, which are conserved from murine to African apes. Protein structural analysis suggested that a putative novel neuropeptide might have originated during human evolution and functioned in the human brain. Our data suggested that the PACAP precursor gene underwent adaptive changes during human origin and may have contributed to the formation of human cognition. |
| Databáze: | OpenAIRE |
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