The utility of ground-glass attenuation score for anticancer treatment-related acute exacerbation of interstitial lung disease among lung cancer patients with interstitial lung disease
| Autor: | Takayuki Honda, Tomoshige Chiaki, Yasuto Jin, Kazuhito Saito, Tatsuo Kawahara, Yasunari Miyazaki, Tomoya Tateishi, Takaaki Yamashita, Yoshikazu Tsukada, Reiko Taki, Ichiro Natsume, Manabu Sema, Yoshihiro Miyashita, Naoki Nishiyama, Hiroyuki Sakashita |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Lung Neoplasms Exacerbation medicine.medical_treatment Treatment of lung cancer 03 medical and health sciences 0302 clinical medicine Antineoplastic Agents Immunological Internal medicine Carcinoma Non-Small-Cell Lung medicine Humans Adverse effect Lung cancer Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Interstitial lung disease Retrospective cohort study Hematology General Medicine respiratory system Middle Aged medicine.disease respiratory tract diseases body regions 030104 developmental biology Logistic Models 030220 oncology & carcinogenesis Cohort Surgery Female business Lung Diseases Interstitial Tomography X-Ray Computed |
| Zdroj: | International journal of clinical oncology. 25(2) |
| ISSN: | 1437-7772 |
| Popis: | Acute exacerbation (AE) of interstitial lung disease (ILD) is a fatal adverse event in the treatment of lung cancer patients with ILD. The value of pre-treatment radiological findings obtained by high-resolution computed tomography for the detection of anticancer treatment-related AE of ILD has not been established. Two medical record-based retrospective studies were performed. The chemotherapy cohort included 105 lung cancer patients with ILD who received chemotherapy at Tokyo Medical and Dental University between October 2008 and December 2017. The immune checkpoint inhibitor (ICI) cohort included 48 advanced non-small cell lung cancer patients with ILD treated with ICIs at nine institutions between January 2016 and September 2018. Variables were compared between AE-positive and -negative groups. Candidate variables were analyzed by multivariate logistic regression. A P value |
| Databáze: | OpenAIRE |
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