Mass Fragmentographic Determination of Plasma Etomidate Concentrations

Autor:	Mohamed M. Ghoneim, John J. Ambre, Michael J. Van Hamme
Rok vydání:	1977
Předmět:	Time Factors Chromatography Chemistry Imidazoles Pharmaceutical Science Plasma Gas Chromatography-Mass Spectrometry Mass fragmentography Etomidate Human plasma Anesthetic Plasma concentration Methods medicine Humans medicine.drug
Zdroj:	Journal of Pharmaceutical Sciences. 66:1344-1346
ISSN:	0022-3549
DOI:	10.1002/jps.2600660939
Popis:	The intravenous anesthetic etomidate was measured in human plasma by mass fragmentography. The method is accurate, sensitive, and specific. Results of the analyses indicate that after a single 0.3-mg/kg iv dose of etomidate, there are at least three phases in its disappearance from human plasma. Detectable plasma concentrations exist for more than 6 hr after injection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8495059212b970b63f94cfd3cfa872 https://doi.org/10.1002/jps.2600660939 Zobrazit plný text záznamu Plný text