Kikuchi-Fujimoto disease diagnosed by correlating skin and lymph node biopsies
| Autor: | Huazhang Guo, M. Yadira Hurley, Mallory S. Abate, Nirav Patel, Erin E. Williams |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty Kikuchi-Fujimoto disease Case Report Dermatology Disease histology SLE systemic lupus erythematosus 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine systemic lupus erythematosus Biopsy Medicine Epstein-Barr virus biopsy necrotizing lymphadenitis dermatopathology Lymph node EBV Epstein-Barr virus biology medicine.diagnostic_test business.industry Parvovirus HIV biology.organism_classification Rash nonneutrophilic karyorrhexis medicine.anatomical_structure 030220 oncology & carcinogenesis Etiology interface dermatitis Human herpesvirus 6 Dermatopathology medicine.symptom business |
| Zdroj: | JAAD Case Reports |
| ISSN: | 2352-5126 |
| Popis: | Kikuchi-Fujimoto disease is a rare, self-limited benign necrotizing lymphadenitis that typically manifests as fever and lymphadenopathy with or without extension to other organs including the skin, eyes, and bone marrow.1, 2 The rash may be variable in appearance, although most commonly presents with erythematous macules, papules, and plaques involving the face, upper extremities, and trunk.3 Because the laboratory findings and imaging are nonspecific, the diagnosis depends on histologic examination. Characteristic histopathologic features of Kikuchi-Fujimoto disease include abundant nuclear debris surrounded by a brisk histiocytic infiltrate with varying degrees of lymphocytes and immunoblasts. Neutrophils are typically absent.2 The etiology of Kikuchi-Fujimoto disease is unknown, although various infections including Epstein-Barr virus (EBV), parvovirus B-19, HIV, and human herpesvirus 6 have been implicated. An association with systemic lupus erythematosus (SLE) has also been reported, although the nature of the relationship is unclear.3 We report a case of Kikuchi-Fujimoto disease in the setting of EBV infection diagnosed following correlation between skin and lymph node biopsies. |
| Databáze: | OpenAIRE |
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