Implicit contextual learning in prodromal and early stage Huntington's disease patients
| Autor: | Filipa Júlio, Marieke Van Asselen, Mário Simoes, Miguel Castelo-Branco, Elzbieta Malgorzata Bobrowicz Campos, Maria Cristina Januário Santos, Inês Alexandra Teixeira de Almeida |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Stimulus (physiology) Audiology Neuropsychological Tests Memorization Huntington's disease Memory Basal ganglia medicine Reaction Time Humans Learning Attention Visual search General Neuroscience Contextual learning Recognition Psychology Middle Aged medicine.disease Implicit learning Psychiatry and Mental health Clinical Psychology Huntington Disease Disease Progression Female Neurology (clinical) Cues Psychology Motor learning psychological phenomena and processes Cognitive psychology |
| Zdroj: | CIÊNCIAVITAE Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | Huntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task. (JINS, 2012, 18, 1–8) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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