Peritoneal Mesothelioma: Clinical and Therapeutic Aspects
| Autor: | Mihaela-Iustina Mesina-Botoran, Mihai Călin Ciorbagiu, Cosmin Vasile Obleaga, Cristian Mesina, Dumitrescu T |
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| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty business.industry InformationSystems_INFORMATIONSTORAGEANDRETRIEVAL respiratory system medicine.disease respiratory tract diseases 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine Peritoneal mesothelioma 030211 gastroenterology & hepatology business GeneralLiterature_REFERENCE(e.g. dictionaries encyclopedias glossaries) neoplasms |
| Popis: | Mesothelioma is a very rare malignant disease that originates from mesothelial cells that line the serosa: pleura, peritoneum, pericardium, or testicular vaginal tunic. Peritoneal mesothelioma accounts for 7–10% of all mesotheliomas diagnosed, and ranks second after pleural localization of mesothelioma. The incidence of peritoneal mesothelioma is 0.5–3 cases per million in men and 0.2–2 cases per million in women. Diagnosis of peritoneal mesothelioma is difficult due to nonspecific symptoms and because of this patients present in advanced stages of the disease. Histologically there are three major categories of malignant peritoneal mesothelioma: epithelioid, sarcomatoid, and biphasic. The differential diagnosis of peritoneal mesothelioma is made with peritoneal pseudomyxoma, ovarian tumors, and peritoneal metastases from colorectal cancer. An important role in differential diagnosis, in addition to immunohistochemistry, is played by various tumor markers and genetic tests. The treatment of peritoneal mesothelioma is performed by cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC), with good results for patients in the early stages of the disease. For patients with advanced disease, a new treatment has been proposed: pressurized intraperitoneal aerosol chemotherapy (PIPAC). For patients who cannot use CRS and HIPEC, the only therapeutic option remains chemotherapy (systemic + intraperitoneal). |
| Databáze: | OpenAIRE |
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