Simultaneous Pancreas and Kidney Transplantation is Associated With Inferior Long-Term Outcomes in African Americans
| Autor: | Anthony DeLeonibus, Madeleine Oliver, Jingning Mei, Donald B. White, Jorge Ortiz, Rong Liu, Eric Siskind, Joseph T. Brooks |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment 030232 urology & nephrology 030230 surgery Pancreas transplantation White People Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Asian People Internal medicine Outcome Assessment Health Care Internal Medicine medicine Humans Young adult Kidney transplantation Retrospective Studies Type 1 diabetes Kidney Hepatology business.industry Graft Survival Retrospective cohort study Hispanic or Latino Middle Aged medicine.disease Kidney Transplantation Black or African American Diabetes Mellitus Type 1 medicine.anatomical_structure Female Graft survival Pancreas Transplantation Pancreas business |
| Zdroj: | Pancreas. 47:116-121 |
| ISSN: | 1536-4828 0885-3177 |
| DOI: | 10.1097/mpa.0000000000000958 |
| Popis: | OBJECTIVES Simultaneous pancreas and kidney transplant (SPK) is the most effective treatment for patients with type 1 diabetes mellitus and renal failure. However, the effect of ethnicity on SPK outcomes is not well understood. METHODS We studied the influence of recipient ethnicity on SPK using the United Network for Organ Sharing database. A retrospective review of 20,196 SPK patients from 1989 to 2014 was performed. The recipients were divided into 4 groups: 15,833 whites (78.40%), 2708 African Americans (AA) (14.39%), 1456 Hispanics (7.21%), and 199 Asians (0.99%). RESULTS Hispanics and Asians experienced the best overall graft and patient outcomes. Both groups demonstrated significantly superior graft and patient survival rates compared with whites at 1, 3, 5, 10, and 15 years (all P < 0.0001). African Americans experienced significantly superior 1- and 3-year patient survival compared with whites (both P < 0.0001). African Americans also experienced significantly superior 1-year kidney and pancreas graft survival compared with whites (P < 0.0001). However, AA experienced significantly inferior patient and allograft outcomes for all other time points compared with whites. CONCLUSIONS Based on United Network for Organ Sharing data from 1989 to 2014, AA have worse long-term patient and graft survival rates compared with whites, Hispanics, and Asians undergoing SPK. |
| Databáze: | OpenAIRE |
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