Anti-inflammatory and anti-nociceptive activity of disodium glycyrrhetinic acid hemiphthalate
| Autor: | T. Samadian, G. Khaksa, Ahmad Reza Dehpour, M. E. Zolfaghari |
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| Předmět: |
Male
medicine.drug_class Sodium Analgesic Pain Pharmaceutical Science chemistry.chemical_element Pharmacology Plant Roots Anti-inflammatory Analytical Chemistry Mice Acetic acid chemistry.chemical_compound Edema Drug Discovery medicine Animals Potency Rats Wistar Analgesics Analysis of Variance Aspirin Plant Extracts Chemistry Anti-Inflammatory Agents Non-Steroidal Organic Chemistry Biological activity Glycyrrhizic Acid Rats Complementary and alternative medicine Biochemistry Glycyrrhetinic Acid Molecular Medicine Female medicine.symptom medicine.drug |
| Zdroj: | Scopus-Elsevier |
| Popis: | The anti-inflammatory and anti-nociceptive effects of disodium glycyrrhetinic acid hemiphthalate (glycyrrhetinic acid 3 beta-O-hemiphthalate sodium) after parenteral administration were determined in several animal models. Disodium glycyrrhetinic acid hemiphthalate (GAP) significantly inhibited the rat paw edema induced by carrageenin (ID50 = 21.37 mg/kg), and mice writhing responses caused by acetic acid (ID50 = 9.12 mg/kg). The potency of disodium glycyrrhetinic acid hemiphthalate was about 13.05 times higher than acetylsalicylic acid in inhibiting rat paw edema and 12.84 times higher in inhibiting abdominal constrictions in mice. |
| Databáze: | OpenAIRE |
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