| Autor: |
Robert C. Bast, Zhen Lu, Gabriel Lopez-Berestein, Anil K. Sood, Ahmed Ashour Ahmed, Nicholas B. Jennings, Lakesla R. Iles, Geoffrey Bartholomeusz, Lingegowda S. Mangala, Cristian Rodriguez-Aguayo, Weiqun Mao, Hailing Yang |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22475030 |
| Popis: |
Table S1. Cell lines and culture media Table S2. GE Dharmacon siRNA catalogues Table S3. Primers Table S4. siRNA transfection conditions for custom screens Table S5. Antibodies for Western blot and immunohistochemistry Table S6. Paclitaxel sensitivity in 12 ovarian cancer cell lines. Table S7. Paclitaxel sensitivity of two siRNA combination in six ovarian cancer cell lines. Table S8. TMA patient information Figure S1. Effects of single kinase siRNA on microtubule stability. Figure S2. Knockdown efficiency was examined in SKOv3ip cells. Figure S3. Sequential treatment of siIKBKB followed by siSTK39 or siEDN2 followed by siTBK1 increases microtubule stability. Figure S4. Sequential treatment of siIKBKB followed by siSTK39 or siEDN2 followed by siTBK1 increases microtubule stability and increasing microtubule stability by depletion of IKBKB/STK39 or EDN2/TBK1 is dependent upon p38-mdiated phosphorylation MAP4. Figure S5. Increasing paclitaxel sensitivity by depletion of IKBKB and TK39 or EDN2 and TBK1 is dependent upon MAP4. Figure S6. Mice tolerate the siRNA and paclitaxel treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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