Evidence for the efficacy of latrepirdine (Dimebon) treatment for improvement of cognitive function: a meta-analysis
| Autor: | Joaquín Jordán, Julián E. Solís-García del Pozo, Nieves Cano-Cuenca |
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| Rok vydání: | 2013 |
| Předmět: |
Indoles
medicine.medical_treatment MEDLINE Disease Neuropsychological Tests Bioinformatics law.invention Huntington's disease Randomized controlled trial law Alzheimer Disease medicine Humans Randomized Controlled Trials as Topic Psychiatric Status Rating Scales business.industry General Neuroscience Latrepirdine Cognition General Medicine medicine.disease Clinical trial Psychiatry and Mental health Clinical Psychology Huntington Disease Meta-analysis Schizophrenia Antihistamine Geriatrics and Gerontology business Cognition Disorders medicine.drug Antipsychotic Agents |
| Zdroj: | Journal of Alzheimer's disease : JAD. 38(1) |
| ISSN: | 1875-8908 |
| Popis: | Over the last few years, latrepirdine, a demode antihistamine drug, has been proposed to be useful for treating neurodegenerative disorders such as Alzheimer's and Huntington's diseases, and more recently schizophrenia. The mechanisms and pharmacological targets that are responsible for the beneficial effects on neurodegenerative diseases remain unknown. But it has been proposed that latrepirdine may modulate several targets including voltage-gate Ca+2 channels, mitochondrial permeability pore transition, or several neurotransmitter receptors. Herein, we present a meta-analysis of randomized controlled trials to ascertain the efficacy and safety of latrepirdine on cognitive function. By doing a search in electronic databases, we found five clinical trials in which the effect of latrepirdine on cognition function has been studied, and this was evaluated using MMSE, ADAS-cog, ADCS-ADL, and NPI scores. Latrepirdine generally presented a good safety profile; it was well tolerated when given alone or in combination with a variety of other drugs. We observed heterogeneous results between trials; latrepirdine failed to exert a significant beneficial effect although it tended to improve cognitive scores. The only significant benefit that we found was for the NPI score in Alzheimer's disease patients. |
| Databáze: | OpenAIRE |
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