Sex differences in oxidative stress resistance in relation to longevity in Drosophila melanogaster
| Autor: | S. Niveditha, Saraf R. Ramesh, S Deepashree, Thimmappa Shivanandappa |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Antioxidant Time Factors Physiology media_common.quotation_subject medicine.medical_treatment Longevity Defence mechanisms medicine.disease_cause Biochemistry Antioxidants Toxicology 03 medical and health sciences Endocrinology Sex Factors Internal medicine medicine Melanogaster Animals Drosophila Proteins Ecology Evolution Behavior and Systematics media_common biology Ethanol Superoxide Dismutase Stressor Age Factors biology.organism_classification Catalase Oxidative Stress 030104 developmental biology Drosophila melanogaster biology.protein Animal Science and Zoology Female Reactive Oxygen Species Oxidative stress Locomotion |
| Zdroj: | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology. 187(7) |
| ISSN: | 1432-136X |
| Popis: | Gender differences in lifespan and aging are known across species. Sex differences in longevity within a species can be useful to understand sex-specific aging. Drosophila melanogaster is a good model to study the problem of sex differences in longevity since females are longer lived than males. There is evidence that stress resistance influences longevity. The objective of this study was to investigate if there is a relationship between sex differences in longevity and oxidative stress resistance in D. melanogaster. We observed a progressive age-dependent decrease in the activity of SOD and catalase, major antioxidant enzymes involved in defense mechanisms against oxidative stress in parallel to the increased ROS levels over time. Longer-lived females showed lower ROS levels and higher antioxidant enzymes than males as a function of age. Using ethanol as a stressor, we have shown differential susceptibility of the sexes to ethanol wherein females exhibited higher resistance to ethanol-induced mortality and locomotor behavior compared to males. Our results show strong correlation between sex differences in oxidative stress resistance, antioxidant defenses and longevity. The study suggests that higher antioxidant defenses in females may confer resistance to oxidative stress, which could be a factor that influences sex-specific aging in D. melanogaster. |
| Databáze: | OpenAIRE |
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