8-OH-DPAT specifically enhances feeding behaviour in mice: evidence from behavioural competition
| Autor: | R.J. Rodgers, Jon K. Shepherd |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Male
Agonist Competitive Behavior medicine.medical_specialty Tetrahydronaphthalenes medicine.drug_class Naphthalenes Developmental psychology Conflict Psychological Ondansetron Mice Basal (phylogenetics) chemistry.chemical_compound Internal medicine Avoidance Learning medicine Animals Social Behavior Pharmacology 8-Hydroxy-2-(di-n-propylamino)tetralin Diazepam Dose-Response Relationship Drug 8-OH-DPAT Imidazoles Antagonist Feeding Behavior Dose–response relationship Endocrinology chemistry Mice Inbred DBA Psychology medicine.drug |
| Zdroj: | Psychopharmacology. 101:408-413 |
| ISSN: | 1432-2072 0033-3158 |
| DOI: | 10.1007/bf02244062 |
| Popis: | The behavioural specificity of the hyperphagic effects of 8-OH-DPAT is a controversial issue. The present study addressed this question through the introduction of behavioural competition. Feeding behaviour in male mice was assessed under both basal (free-feeding) and social conflict conditions. Since, in the latter condition, defence and escape are prepotent responses, elicitation of feeding would be indicative of a specific treatment effect on mechanisms controlling food intake. Results showed that 8-OH-DPAT enhanced basal feeding duration (at doses of 0.05–0.50 mg/kg) and also elicited feeding in intruder mice during encounters with aggressive resident conspecifics (at doses of 0.10–0.50 mg/kg). As the 5-HT3 antagonist GR 38032F (1.0–2.0 mg/kg) enhanced feeding only under basal conditions, the effect of 8-OH-DPAT cannot readily be attributed to anxiety reduction. Finally, diazepam (1.0–2.0 mg/kg) produced a similar profile to that of 8-OH-DPAT, suggesting that the hyperphagic effects of the 5-HT1A agonist are not pharmacologically specific. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink