Patients with Alzheimer disease have altered transmitral flow: echocardiographic analysis of the vortex formation time
| Autor: | Panupong Jiamsripong, Marwan N. Sabbagh, Eileen M. McMahon, Chera L. Maarouf, Thomas G. Beach, Zsolt Garami, Teresa L. Chaffin, Anna M. Calleja, Tyler A. Kokjohn, Linda Vedders, Marek Belohlavek, Alex E. Roher |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Cardiovascular risk factors Diastole Ventricular Dysfunction Left Alzheimer Disease Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Interventricular septum Aged Radiological and Ultrasound Technology Vortex Formation business.industry Stroke Volume Stroke volume medicine.disease Normal limit Surgery Increased risk medicine.anatomical_structure Echocardiography Cardiology Mitral Valve Female Alzheimer's disease business Blood Flow Velocity |
| Zdroj: | Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 28(11) |
| ISSN: | 1550-9613 |
| Popis: | OBJECTIVE There is considerable epidemiologic evidence that Alzheimer disease (AD) is linked to cardiovascular risk factors and associated with an increased risk of symptomatic left ventricular (LV) dysfunction. Formation of a vortex alongside a diastolic jet signifies an efficient blood transport mechanism. The vortex formation time (VFT) is an index of optimal conditions for vortex formation. We hypothesized that AD and its associated cardiovascular risk factors impair diastolic transmitral flow efficiency and, therefore, shift the VFT value out of its optimal range. METHODS Echocardiographic studies were performed on 45 participants in total: 22 patients with AD diagnosed according to the American Psychiatric Association's criteria and 23 age-matched individuals as a control group with cognitive function within normal limits. RESULTS The echocardiographic ratio of the early to atrial phases of the LV filling velocities was significantly lower in the AD group (mean +/- SD, 0.67 +/- 14) when compared with the control individuals (0.79 +/- 0.14; P = .003). The interventricular septum diastolic thickness, left ventricular posterior wall diastolic thickness, and right ventricular end-diastolic diameter were significantly higher in the AD group (P |
| Databáze: | OpenAIRE |
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