The FAGenomicH project: Towards a whole candidate gene approach to identify markers associated with fatness and production traits in pigs and investigate the pig as a model for human obesity
| Autor: | Elena Bonora, Giuliano Galimberti, Camilla Speroni, Luca Fontanesi, Raffaele Fronza, Emilio Scotti, Vincenzo Russo, Michela Colombo, Daniela Giovanna Calo, Giovanni Romeo, Lucia Tognazzi, Rita Casadio, Manuela Vargiolu |
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| Přispěvatelé: | Fontanesi L., Fronza R., Scotti E., Colombo M., Speroni C., Tognazzi L., Galimberti G., Calò DG, Bonora E., Vargiolu M., Romeo G., Casadio R., Russo V. |
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| Zdroj: | Scopus-Elsevier Italian Journal of Animal Science, Vol 8, Iss 2s, Pp 87-89 (2010) |
| Popis: | Fatness in pigs is a complex trait for which a large number of genes are expected to be involved. Genetics of human obesity could take advantages from genetic information coming from the pig and vice versa. To these aims, a comprehensive candidate gene approach could be helpful. We catalogued all genes affecting fatness on both species, and identified in silico and by resequencing porcine SNPs on a large number of candidate genes. In addition, we applied a selective genotyping approach to identify markers associated with fat deposition in pigs. This approach was tested genotyping the IGF2 intron3-g.3072G>A mutation and novel markers in the PCSK1 and TBC1D1 genes. Polymorphisms in these genes resulted associated with back fat thickness in Italian Large White pigs. |
| Databáze: | OpenAIRE |
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