MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy
| Autor: | Henrik J. Ditzel, Behzad Baradaran, Elham Safarzadeh, William C. Cho, Morten F. Gjerstorff, Behzad Mansoori, Pascal H.G. Duijf, Ali Mohammadi |
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| Přispěvatelé: | Mansoori, Behzad, Duijf, Pascal HG, Mohammadi, Ali, Safarzadeh, Elham, Ditzel, Henrik J, Gjerstorff, Morten F, Cho, William Chi-Shing, Baradaran, Behzad |
| Rok vydání: | 2021 |
| Předmět: |
Untranslated region
HMGA2 miR-142-3p Breast Neoplasms Apoptosis Breast Neoplasms/genetics Malignancy General Biochemistry Genetics and Molecular Biology STAT3 Breast cancer Cell Movement Cancer stem cell Gene expression microRNA Biomarkers Tumor Tumor Cells Cultured medicine Humans General Pharmacology Toxicology and Pharmaceutics Cell Proliferation biology Cancer stem cells business.industry AKT HMGA2 Protein Cell Cycle General Medicine Cell cycle Prognosis medicine.disease HMGA2 Protein/genetics Gene Expression Regulation Neoplastic Survival Rate MicroRNAs ERK MicroRNAs/genetics biology.protein Cancer research Female Biomarkers Tumor/genetics business |
| Zdroj: | Mansoori, B, Duijf, P H G, Mohammadi, A, Safarzadeh, E, Ditzel, H J, Gjerstorff, M F, Cho, W C S & Baradaran, B 2021, ' MiR-142-3p targets HMGA2 and suppresses breast cancer malignancy ', Life Sciences, vol. 276, 119431 . https://doi.org/10.1016/j.lfs.2021.119431 |
| ISSN: | 0024-3205 |
| Popis: | MicroRNAs (miRNAs) have the ability to regulate gene expression programs in cells. Hence, altered expression of miRNAs significantly contributes to breast cancer development and progression. Here, we demonstrate that the miRNA miR-142-3p directly targets the 3′ untranslated region of HMGA2, which encodes an onco-embryonic protein that is overexpressed in most cancers, including breast cancer. Down regulation of miR-142-3p predicting poor patient survival in grade 3 breast cancer (P-value = 0.045). MiR-142-3p downregulates HMGA2 mRNA and protein levels. Higher miR-142-3p and lower HMGA2 expressed are found in breast cancer versus normal breast tissue (P-value |
| Databáze: | OpenAIRE |
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