The inhibition of tumour growth by enzymes in tissue culture
| Autor: | J.A. Dudgeon, G.C. Easty, E.J. Ambrose, D.M. Easty |
|---|---|
| Rok vydání: | 1961 |
| Předmět: |
chemistry.chemical_classification
biology Acid phosphatase Neoplasms Experimental Cell Biology Lipid structure Trypsin Enzymes Cell biology Tissue Culture Techniques Cell membrane Tissue culture Enzyme medicine.anatomical_structure chemistry Biochemistry Neoplasms Homologous chromosome medicine biology.protein Animals Lipase medicine.drug |
| Zdroj: | Experimental Cell Research. 24:220-227 |
| ISSN: | 0014-4827 |
| DOI: | 10.1016/0014-4827(61)90424-4 |
| Popis: | The surfaces of tumour cells show decreased adhesiveness, increased negative surface charge and altered contacts when compared with homologous normal cells. An attempt has been made to characterise these changes in more detail by studying the effects of enzymes on the living cells. Trypsin, a lipase, and acid phosphatase affect both the adhesiveness and the growth rates of the cells. The lipase has been found to act selectively on the growth of tumour cells in culture when compared with homologous normal cells. It is suggested that the altered surface properties of tumour cells are associated with an altered lipid structure of the cell membrane. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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