Use of Doppler ultrasonography in the assessment of bronchodilator response in acute bronchiolitis
| Autor: | Maria Eliopoulou, Theodore Kanellopoulos, Christina Kalogeropoulou, Michael B. Anthracopoulos, Spiridon Yarmenitis, Dimitris A. Papanastasiou |
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| Rok vydání: | 2007 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty medicine.drug_class Hepatic Veins Renal Veins Bronchodilator Internal medicine Administration Inhalation Medicine Humans Albuterol Prospective Studies Vein First episode medicine.diagnostic_test business.industry Nebulizers and Vaporizers Infant Newborn Infant Ultrasonography Doppler medicine.disease Confidence interval Surgery Bronchodilator Agents Pulse oximetry medicine.anatomical_structure Treatment Outcome Bronchiolitis Child Preschool Pediatrics Perinatology and Child Health Acute Disease Salbutamol Cardiology Crackles Female medicine.symptom business Blood Flow Velocity medicine.drug Follow-Up Studies |
| Zdroj: | Pediatric pulmonology. 42(12) |
| ISSN: | 8755-6863 |
| Popis: | Measurement of the response of acute bronchiolitis (AB) to bronchodilators relies on clinical signs and pulse oximetry. We hypothesized that Doppler ultrasonographic indices of hepatic venous flow may prove to be an objective tool in the assessment of the effect of inhaled salbutamol in infants hospitalized for AB. Previously healthy infants hospitalized for their first episode of AB were prospectively studied. Composite clinical score (CCS, retractions plus wheezing/crackles) and hemoglobin oxygen saturation (SaO2) were measured before, and 15-min post-salbutamol nebulization (0.15 mg/kg, minimum 1.5 mg). Peak velocities at the middle hepatic vein (PV-HV) and right renal vein (PV-RV), as well as peripheral-to-middle hepatic vein transit time (TT) of an ultrasound contrast agent were also measured by Doppler ultrasonography pre- and post-nebulization. Nineteen infants were studied. Mean CCS decreased by 0.37 (95% confidence interval [CI]: 0.08–0.66, P = 0.015) and mean SaO2 increased by 0.68% (95%CI: 0.17–1.19, P = 0.01) post-bronchodilator treatment. Mean TT increased by 9.54 sec (95%CI: 5.95–13.13, P |
| Databáze: | OpenAIRE |
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