Data Supplement from Src Kinase Is a Novel Therapeutic Target in Lymphangioleiomyomatosis

Autor: N. Tony Eissa, Abhisek Bhattacharya, Alexey Tyryshkin
Rok vydání: 2023
DOI: 10.1158/0008-5472.22402134.v1
Popis: Increased phospho-Src in LAM lungs (Figure S1); Enhanced activation of Src, STAT3 and Snail in human LAM cells (Figure S2); mTOR activation in TSC2-deficient cells (Figure S3); Src kinase is activated in TSC2-deficient cells (Figure S4); Knockdown of TSC2 in Hela cells up-regulates mTOR activity (Figure S5); Autophagy inhibition results in Src kinase activation (Figure S6); Effects of Src inhibition on migration activity of EEF cells (Figure S7); Src kinase inhibitors decrease proliferation of TSC2-/- cells (Figure S8); Proposed model of Src role in LAM (Figure S9).
Databáze: OpenAIRE