Tobacco smoke is phototoxic
| Autor: | U. Kerkmann, Susanne A. Bell, P. Koepke, Bernhard Przybilla, Marianne Placzek |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Skin ageing Erythrocytes Ultraviolet Rays Dermatology Pharmacology Hemolysis Tobacco smoke Skin Aging Smoke Tobacco medicine Humans Cells Cultured Chemistry Dose-Response Relationship Radiation Haemolysis Dose–response relationship Ageing Toxicity Female Phototoxicity Dermatitis Phototoxic |
| Zdroj: | British Journal of Dermatology. 150:991-993 |
| ISSN: | 1365-2133 0007-0963 |
| DOI: | 10.1111/j.1365-2133.2004.05818.x |
| Popis: | Summary Background Both cigarette smoke and ultraviolet (UV) radiation are known to cause changes of the skin which can be regarded as premature ageing. Objectives To assess the theory that the effects of these two exposures could be linked by a phototoxic action of cigarette smoke. Methods A photohaemolysis test was used, in which human erythrocytes were incubated with cigarette smoke condensate, followed by UV irradiation and measurement of exposure-dependent haemolysis. Results Cigarette smoke condensate was clearly phototoxic. Photohaemolysis depended on the concentration of the condensate and UV dose and was more pronounced after exposure to UVA-rich than UVB-rich radiation. Conclusions Phototoxicity may be a mechanism by which cigarette smoking causes premature skin ageing. An enhancing effect on photocarcinogenesis has also to be considered. |
| Databáze: | OpenAIRE |
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