Purification of cyclotron-produced 203Pb for labeling Herceptin
| Autor: | Paul S. Plascjak, Diane E. Milenic, Martin W. Brechbiel, Erik D. Brady, Kayhan Garmestani |
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| Rok vydání: | 2005 |
| Předmět: |
Cancer Research
Metabolic Clearance Rate Radioimmunoconjugate medicine.drug_class Mice Nude Antibodies Monoclonal Humanized Monoclonal antibody Mice In vivo Cell Line Tumor Metabolic clearance rate medicine Animals Humans Tissue Distribution Radiology Nuclear Medicine and imaging Tissue distribution Chromatography Chemistry Carcinoma Antibodies Monoclonal Lead Radioisotopes Cyclotrons Radioimmunotherapy Trastuzumab Organ Specificity Isotope Labeling Colonic Neoplasms Molecular Medicine Female Radiopharmaceuticals |
| Zdroj: | Nuclear Medicine and Biology. 32:301-305 |
| ISSN: | 0969-8051 |
| Popis: | A simple and rapid procedure was developed for the purification of cyclotron-produced 203Pb via the 203Tl(d,2n) 203Pb reaction. A Pb(II) selective ion-exchange resin, with commercial name Pb Resin from Eichrom Technologies, Inc., was used to purify 203Pb from the cyclotron-irradiated Tl target with excellent recovery of the enriched Tl target material. The purified 203Pb was used to radiolabel the monoclonal antibody Herceptin. The in vitro and in vivo properties of the 203Pb radioimmunoconjugate were evaluated. |
| Databáze: | OpenAIRE |
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