Effect of polyamines on cyclic AMP-dependent and independent protein kinases from mouse epidermis
| Autor: | Andrew W. Murray, Mario Froscio, Anne Rogers |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Spermidine
Biophysics Spermine Protamine Kinase Biology Histone kinase activity Biochemistry Mice chemistry.chemical_compound Casein Cyclic AMP Putrescine Animals Molecular Biology Skin Kinase Muscles Myocardium Cell Biology Rats Cell biology Enzyme Activation Kinetics Adipose Tissue Liver chemistry Mouse Epidermis Organ Specificity Phosphorylation Female Rabbits Protein Kinases |
| Zdroj: | Biochemical and Biophysical Research Communications. 71:1175-1181 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/0006-291x(76)90777-4 |
| Popis: | Soluble extracts from mouse epidermis contained both cyclic AMP-dependent and independent protein kinases which could be separated by DEAE-Sephadex chromatography. The cyclic AMP-dependent histone kinase activity was inhibited by millimolar concentrations of the polyamines putrescine, spermidine and spermine. Similar concentrations of polyamines stimulated the cyclic AMP-independent phosphorylation of casein. The polyamines did not inhibit cyclic AMP binding by soluble epidermal extracts. |
| Databáze: | OpenAIRE |
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