Impaired resting vagal tone in patients with functional movement disorders
| Autor: | Ryan Toledo, Kathrin LaFaver, Mark Hallett, Victoria D. Liu, Steven A. Epstein, Tianxia Wu, Rezvan Ameli, Carine W. Maurer |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Rest Autonomic Nervous System Article 050105 experimental psychology Electrocardiography 03 medical and health sciences 0302 clinical medicine Heart Rate Internal medicine Heart rate medicine Humans Heart rate variability 0501 psychology and cognitive sciences Vagal tone Depression (differential diagnoses) Depressive Disorder Movement Disorders Resting state fMRI 05 social sciences Beck Depression Inventory Heart Vagus Nerve Middle Aged Anxiety Disorders Autonomic nervous system Endocrinology Neurology Cardiology Anxiety Female Neurology (clinical) Geriatrics and Gerontology medicine.symptom Psychology Stress Psychological 030217 neurology & neurosurgery |
| Zdroj: | Parkinsonism & Related Disorders. 30:18-22 |
| ISSN: | 1353-8020 |
| Popis: | Introduction The autonomic nervous system plays an integral role in the maintenance of homeostasis during times of stress. The functioning of the autonomic nervous system in patients with functional movement disorders (FMD) is of particular interest given the hypothesis that converted psychological stress plays a critical role in FMD disease pathogenesis. We sought to investigate autonomic nervous system activity in FMD patients by examining heart rate variability (HRV), a quantitative marker of autonomic function. Methods 35 clinically definite FMD patients and 38 age- and sex-matched healthy controls were hospitalized overnight for continuous electrocardiogram recording. Standard time and frequency domain measures of HRV were calculated in the awake and asleep stages. All participants underwent a thorough neuropsychological battery, including the Hamilton Anxiety and Depression scales and the Beck Depression Inventory. Results Compared to controls, patients with FMD exhibited decreased root mean square of successive differences between adjacent NN intervals (RMSSD) (p = 0.02), a marker of parasympathetic activity, as well as increased mean heart rate (p = 0.03). These measures did not correlate with the depression and anxiety scores included in our assessment as potential covariates. Conclusion In this exploratory study, patients with FMD showed evidence of impaired resting state vagal tone, as demonstrated by reduced RMSSD. This decreased vagal tone may reflect increased stress vulnerability in patients with FMD. |
| Databáze: | OpenAIRE |
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