Protective effects of aloperine on neonatal rat primary cultured hippocampal neurons injured by oxygen–glucose deprivation and reperfusion
| Autor: | Lin Ma, Cheng-Jun Zhao, Wei Li, Tao Sun, Yu-Xiang Li, Shao-Ju Jin, Yang Niu, Yin-Ju Hao, Juan Du, Jian-Qiang Yu, Ren-Yuan Chang, Kazuo Koike, Ning-Tian Ma, Ru Zhou, Jie Zheng |
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| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Quinolizidines Antioxidant medicine.medical_treatment Apoptosis Hippocampus Neuroprotection Rats Sprague-Dawley Superoxide dismutase chemistry.chemical_compound Piperidines Internal medicine medicine Animals Viability assay Neurons chemistry.chemical_classification biology Glutathione peroxidase Malondialdehyde Rats Oxygen Glucose Neuroprotective Agents Endocrinology chemistry Biochemistry Catalase Reperfusion Injury biology.protein Molecular Medicine |
| Zdroj: | Journal of Natural Medicines. 69:575-583 |
| ISSN: | 1861-0293 1340-3443 |
| DOI: | 10.1007/s11418-015-0928-2 |
| Popis: | Aloperine (ALO), one of the alkaloids isolated from Sophora alopecuroides L., is traditionally used for various diseases including neuronal disorders. This study investigated the protective effects of ALO on neonatal rat primary-cultured hippocampal neurons injured by oxygen–glucose deprivation and reperfusion (OGD/RP). Treatment with ALO (25, 50, and 100 mg/l) attenuated neuronal damage (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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