Analysis of CYP17, CYP19 and CYP1A1 Gene Polymorphisms in Iranian Women with Breast Cancer
| Autor: | Farah Farzaneh, Giti Noghabaei, Esmat Barouti, Farkhondeh Pouresmaili, Javad Jamshidi, Atena Fazeli, Shaghayegh Taghavi, Babak Emamalizadeh, Hossein Darvish |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Cancer Research medicine.medical_specialty Epidemiology medicine.medical_treatment Breast Neoplasms Iran Polymerase Chain Reaction Polymorphism Single Nucleotide 03 medical and health sciences Aromatase 0302 clinical medicine Breast cancer Internal medicine Genotype Biomarkers Tumor Cytochrome P-450 CYP1A1 medicine Genetic predisposition Humans Allele Neoplasm Staging business.industry Public Health Environmental and Occupational Health Case-control study Steroid 17-alpha-Hydroxylase Middle Aged Prognosis medicine.disease Genotype frequency Steroid hormone 030104 developmental biology Case-Control Studies 030220 oncology & carcinogenesis Etiology Female business Polymorphism Restriction Fragment Length Follow-Up Studies |
| Zdroj: | Asian Pacific Journal of Cancer Prevention. 17:23-26 |
| ISSN: | 1513-7368 |
| DOI: | 10.7314/apjcp.2016.17.s3.23 |
| Popis: | Breast cancer (BC) is the most common cancer and the second cause of mortality in women all around the world. It is caused by several factors including genetic determinants, so that both genetic susceptibility factors and environmental factors are involved in the etiology. Significance of genes functioning in steroid hormone synthesis and metabolism are well established in breast cancer susceptibility. In this study, 134 women with BC and 135 normal controls were analyzed for their genotypes for the polymorphisms, rs743572, rs10046 and rs4646903, resided in CYP17, CYP19 and CYP1A1 genes, respectively. Significant differences in distributions of allele and genotype frequencies were found for the rs10046 polymorphism in CYP19 (p-value=0.01, OR (CI 95%) =1.59 (1.1-2.3), p-value=0.04, OR (CI 95%) =1.7 (1.1-2.5) respectively). For rs743,572 and rs 4646903 polymorphisms, no significant associations were observed. A significant association was observed between the rs10046 polymorphism of the CYP19gene and breast cancer in Iranian patients. Due to inconsistent previous results, more studies in different populations with larger sample sizes are indicated. |
| Databáze: | OpenAIRE |
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