Lipoprotein and lecithin: cholesterol acyltransferase changes in galactosamine-induced rat liver injury
| Autor: | Seymour M. Sabesin, James B. Ragland, L. B. Kuiken |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Very low-density lipoprotein
food.ingredient Lipoproteins Sterol O-acyltransferase Phospholipid Galactosamine Lecithin Lipid Metabolism Inborn Errors Phosphatidylcholine-Sterol O-Acyltransferase chemistry.chemical_compound food Lecithin Cholesterol Acyltransferase Deficiency medicine Animals Intermediate-density lipoprotein Lecithin cholesterol acyltransferase deficiency Multidisciplinary Liver Diseases Reverse cholesterol transport medicine.disease Rats Disease Models Animal Biochemistry chemistry lipids (amino acids peptides and proteins) Female Cholesterol Esters Chemical and Drug Induced Liver Injury Apoproteins Acyltransferases Lipoprotein |
| Zdroj: | Science (New York, N.Y.). 190(4221) |
| ISSN: | 0036-8075 |
| Popis: | Abnormal lipoproteins and drcreased lecithin: cholesterol acyltransferase activity are found in rat plasma following intraperitoneal injection of D-galactosamine. The changes observed, including absence of alpha-lipoprotein and the presence of lipoproteins rich in phospholipid and unesterified cholesterol but deficient in cholesteryl esters, are remarkably similar to changes found in human pathologic states of lecithin: cholesterol acyltransferase deficiency. When examined by electron microscopy, all of the major lipoprotein classes isolated by ultracentrifugation showed morphological abnormalities including the formation of rouleaus consisting of disk-shaped particles. |
| Databáze: | OpenAIRE |
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