Does a history of malignancy impact the survival of a subsequent endometrial adenocarcinoma? Should clinical trials eligibility criteria be revisited?
| Autor: | Ahmed M. Afifi, Anas M. Saad, Muneer J. Al-Husseini, Hadeer Mohamed, Mai Ibrahim Sokkar, Sali K. Albarouki |
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| Rok vydání: | 2019 |
| Předmět: |
Oncology
Adult medicine.medical_specialty Seer database Kaplan-Meier Estimate Adenocarcinoma Malignancy Cancer specific survival 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Overall survival Humans Aged Neoplasm Staging Proportional Hazards Models Endometrial adenocarcinoma Clinical Trials as Topic 030219 obstetrics & reproductive medicine business.industry Patient Selection Obstetrics and Gynecology Neoplasms Second Primary Middle Aged medicine.disease Endometrial Neoplasms Clinical trial 030220 oncology & carcinogenesis Female business SEER Program |
| Zdroj: | Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 40(2) |
| ISSN: | 1364-6893 |
| Popis: | We aimed at finding the impact of prior malignancies on the survival of patients with endometrial adenocarcinoma using SEER database (from 1973 to 2014). We identified 127,988 patients who were diagnosed with endometrial adenocarcinoma (6485 had a prior malignancy), and we compared the overall and cancer-specific survival based on the presence or absence of a prior malignancy and the latency period between the two diagnoses using Kaplan-Meier test and Cox models. Adjusted cox models showed that a history of a prior malignancy neither affected the overall survival nor the cancer-specific survival of stage IV cases in all latency groups except the one diagnosed within 1 year of the first cancer. Therefore, there is no rational explanation for excluding stage IV endometrial adenocarcinoma patients with a prior malignancy from clinical trials except for the group that was diagnosed with endometrial adenocarcinoma within 1 year from the first cancer.Impact statement |
| Databáze: | OpenAIRE |
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