Vascular Smooth Muscle Cell Differentiation in Human Cerebral Vascular Malformations
| Autor: | Jung H. Kim, Nikolay I. Baev, Issam A. Awad, Ryunosuke Uranishi |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Intracranial Arteriovenous Malformations Male Pathology medicine.medical_specialty Myosin light-chain kinase Vascular smooth muscle Adolescent Cell Culture Techniques Connective tissue Biology Antibodies Muscle Smooth Vascular Culture Techniques Myosin medicine Humans Myosin Heavy Chains Vascular disease Cell Differentiation Smooth Muscle Myosins Anatomy Middle Aged medicine.disease Immunohistochemistry Actins medicine.anatomical_structure Vascular smooth muscle cell differentiation Smoothelin Female Surgery Neurology (clinical) |
| Zdroj: | Neurosurgery. 49:671-680 |
| ISSN: | 0148-396X |
| Popis: | OBJECTIVE The pathogenesis of central nervous system vascular malformations likely involves the abnormal assembly, differentiation of vascular smooth muscle cells (VSMC), or both in association with dysmorphic vessel wall. We hypothesize that intracranial arteriovenous malformations (AVMs) and cerebral cavernous malformations (CCMs) exhibit distinct patterns of expression of molecular markers of differentiation and maturity of VSMCs. We further speculate that the unique VSMC phenotype in the different lesions is not necessarily maintained in cell culture. METHODS Paraffin-embedded sections of five AVMs, CCMs, and control brain tissues were stained immunohistochemically with antibodies to alpha-smooth muscle actin (alpha-SMA), myosin heavy chain, and smoothelin, a novel marker for contractile VSMC phenotype. Large (> or =100 microm) and small ( |
| Databáze: | OpenAIRE |
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