Whey prefermented with beneficial microbes modulates immune response and lowers responsiveness to milk allergens in mouse model
| Autor: | Ewa Wasilewska, Anna Maria Szyc, Barbara Wróblewska, Lidia Hanna Markiewicz, Anna Kaliszewska-Suchodoła |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Medicine (miscellaneous) Gut microbiota Immunomodulation 03 medical and health sciences fluids and secretions 0404 agricultural biotechnology Immune system Antigen Whey Lactobacillus TX341-641 Secretion Food science 030109 nutrition & dietetics Nutrition and Dietetics biology Nutrition. Foods and food supply Chemistry Immunogenicity food and beverages 04 agricultural and veterinary sciences biology.organism_classification 040401 food science Beneficial microbes Bifidobacterium animalis Streptococcus salivarius Cow’s milk allergy Fermentation bacteria Lactobacillus plantarum Food Science |
| Zdroj: | Journal of Functional Foods, Vol 54, Iss, Pp 41-52 (2019) |
| ISSN: | 1756-4646 |
| Popis: | Whey is a rich dairy by-product emerging mostly during cheese production, with valuable nutritional, functional and bioactive properties and reduced immunogenicity of the protein fractions. The aim of the study was to evaluate therapeutic potential and immunoreactivity with milk antigens of whey prefermented with potentially probiotic bacteria (with Streptococcus salivarius subsp. thermophilus 2 K and Lactobacillus delbrueckii subsp. bulgaricus BK – FW whey, or with S. thermophilus 2 K, L. bulgaricus BK, Lactobacillus plantarum W42, and Bifidobacterium animalis ssp. lactis Bi30 – FW-LB whey). The study was conducted on a mice model with induced cow’s milk proteins allergy (CMPA). Interventional feeding of α-CN + β-LG immunized mice with FW and FW-LB whey changed Th1/Th2 balance towards a Th1 response and enhanced the secretion of regulatory cytokines, and reduced allergy markers level. The presence of L. plantarum W42 and B. lactis Bi30 significantly enhanced the observed therapeutic effect of whey prefermented with yogurt cultures. |
| Databáze: | OpenAIRE |
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