Alteration of circulating type 2 follicular helper T cells and regulatory B cells underlies the comorbid association of allergic rhinitis with bronchial asthma
| Autor: | Katsunori Shigehara, Sumito Jitsukawa, Noriko Ogasawara, Shingo Ichimiya, Keiji Yamashita, Tetsuo Himi, Ryuta Kamekura, Yasuo Kokai, Kenichi Takano, Satsuki Miyajima, Hiroshi Matsumiya, Akinori Sato, Koji Kawata, Nobuhiko Seki, Ayako Kumagai, Hiroki Takahashi, Tomonori Nagaya |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Regulatory B cells Immunology Cell Peripheral blood mononuclear cell Allergic rhinitis Young Adult immune system diseases Internal medicine Follicular phase medicine Humans Immunology and Allergy Bronchial asthma Tfh2 cells Asthma B-Lymphocytes Regulatory business.industry T-Lymphocytes Helper-Inducer Middle Aged medicine.disease Rhinitis Allergic Pathophysiology respiratory tract diseases medicine.anatomical_structure Endocrinology Gene Expression Regulation Case-Control Studies Exhaled nitric oxide Female Tfh cells business Helper t-cells |
| Zdroj: | Clinical Immunology. 158:204-211 |
| ISSN: | 1521-6616 |
| DOI: | 10.1016/j.clim.2015.02.016 |
| Popis: | Allergic rhinitis (AR), the most common allergic disorder of the airway, is often accompanied by bronchial asthma. However, little is known about the mechanism by which AR advances to AR comorbid with bronchial asthma (AR+Asthma). To determine the pathophysiologic features of AR and AR+Asthma, we examined subsets of follicular helper T (Tfh) cells and regulatory B (Breg) cells in peripheral blood from AR and AR+Asthma patients. The results showed polarization of Tfh2 cells within Tfh cell subsets in both AR and AR+Asthma cases. Interestingly, the %Breg cells in total B cells were decreased in AR cases and, more extensively, in AR+Asthma cases. Moreover, we found significant correlations of fractional exhaled nitric oxide and blood eosinophil levels with the index %Tfh2 cells per %Breg cells. Our findings indicate that relative decrease in Breg cells under the condition of Tfh2 cell skewing is a putative exaggerating factor of AR to bronchial asthma. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect