Marker-free automated histopathological annotation of lung tumour subtypes by FTIR imaging
| Autor: | Dirk Theegarten, Matthias Altmayer, Frederik Großerueschkamp, Thomas Behrens, Klaus Gerwert, Angela Kallenbach-Thieltges, Thomas Brüning, Georgios Stamatis |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Pathology Lung Neoplasms Medizin Adenocarcinoma Biochemistry Analytical Chemistry Automation Optical imaging Spectroscopy Fourier Transform Infrared Electrochemistry medicine Environmental Chemistry Humans Marker free Spectroscopy business.industry Optical Imaging Reproducibility of Results medicine.disease Histopathology Female Sample collection Lung tumours business |
| Zdroj: | The Analyst. 140(7) |
| ISSN: | 1364-5528 |
| Popis: | By integration of FTIR imaging and a novel trained random forest classifier, lung tumour classes and subtypes of adenocarcinoma are identified in fresh-frozen tissue slides automated and marker-free. The tissue slices are collected under standard operation procedures within our consortium and characterized by current gold standards in histopathology. In addition, meta data of the patients are taken. The improved standards on sample collection and characterization results in higher accuracy and reproducibility as compared to former studies and allows here for the first time the identification of adenocarcinoma subtypes by this approach. The differentiation of subtypes is especially important for prognosis and therapeutic decision. |
| Databáze: | OpenAIRE |
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