Variations in cervical IL-10 and IL-8 concentrations throughout gestation in normal pregnancies
| Autor: | John C. Smulian, Cande V. Ananth, Nazeeh Hanna, Myriam Mondestin-Sorrentino, Anthony M. Vintzileos, Surendra Sharma, David Sorrentino |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
medicine.medical_specialty Cross-sectional study Pregnancy Trimester Third Immunology Andrology Pregnancy Immunology and Allergy Medicine Humans Interleukin 8 Gynecology Analysis of Variance business.industry Interleukin-18 Obstetrics and Gynecology Gestational age medicine.disease United States Interleukin-10 Interleukin 10 Pregnancy Trimester First Cross-Sectional Studies Reproductive Medicine Pregnancy Trimester Second Cervix Mucus Gestation Interleukin 18 Female Analysis of variance business Biomarkers |
| Zdroj: | American journal of reproductive immunology (New York, N.Y. : 1989). 57(6) |
| ISSN: | 1046-7408 |
| Popis: | Problem Data regarding cervical interleukin 18 (IL-8) and IL-10 concentrations during pregnancy is limited. Method of study This was a cross sectional study of healthy pregnant women. Specimens were collected from the cervical os secretions. IL-8 and IL-10 levels were measured by using enzyme-linked immunosorbent assay. Median (range) cytokine concentrations were derived for each trimester and compared across trimesters. The relationship between gestational age and cytokine levels was assessed by regression analysis. The mean of the ratios of IL-8 to IL-10 was compared in each trimester using anova. Results The median (range) IL-8 concentrations in cervical secretions were in pg/mL: 1562 (1210–4100), 2460 (1047–4688), 3660 (1451–4748) (P |
| Databáze: | OpenAIRE |
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