Morphological effects of isoflavones (daidzein and genistein) on hypothalamic oxytocin neurons in the neonatal mouse brain slice cultures
| Autor: | Ryoichi Yoshimura, Erika Yamamoto, Yasuhisa Endo |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Genistein Biology Oxytocin Supraoptic nucleus Mice chemistry.chemical_compound Organ Culture Techniques Slice preparation Internal medicine medicine Animals Neurons Mice Inbred BALB C General Neuroscience Daidzein Isoflavones Endocrinology Animals Newborn nervous system chemistry Female Infant animal Phytoestrogens Supraoptic Nucleus hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | Neuroscience Letters. 505:87-92 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2011.09.067 |
| Popis: | In adults, oxytocin (OXT) has various central functions including social behavior and reproduction. Many of these functions are steroid dependent and are also influenced by naturally occurring phytoestrogens, isoflavones (IFs). The aim of this study was, therefore, to clarify the effects of IFs on OXT neurons in the brain. In particular, the influence of IFs on the central OXT system of infant animal needs to be examined, because IFs are increasingly consumed for weaning as well as dietary supplements. We have morphologically analyzed the central OXT neurons in neonatal mice using slice cultures treated with IFs, daidzein (Ddz) and genistein (Gen). In the supraoptic nucleus (SON) of male mice, Gen decreased the size of OXT neurons, but not of female nor in the paraventricular hypothalamic nucleus (PVN) of neither gender. In female PVN, Ddz and 17β-estradiol (E(2)) increased the frequencies of varicosity on neurites in small OXT neurons ( |
| Databáze: | OpenAIRE |
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