Exercise and Cyclic Light Preconditioning Protect Against Light-Induced Retinal Degeneration and Evoke Similar Gene Expression Patterns
| Autor: | Preston E Girardot, Micah A Chrenek, Jessica L. Johnson, John M. Nickerson, Priscila P Cunha, Vincent T. Ciavatta, Eric C. Lawson, Jana T Sellers, Moon K. Han, Machelle T. Pardue, Cristina Kendall, Marissa A. Gogniat, Adam M. Hanif, Jeffrey H Boatright |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Retinal degeneration Light Photoperiod Biology Leukemia Inhibitory Factor Retina Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Physical Conditioning Animal Gene expression Electroretinography medicine Animals Aerobic exercise Mice Inbred BALB C medicine.diagnostic_test Reverse Transcriptase Polymerase Chain Reaction Retinal Degeneration Retinal Anatomy medicine.disease Cell biology medicine.anatomical_structure chemistry 030221 ophthalmology & optometry Transcriptome Erg Leukemia inhibitory factor 030217 neurology & neurosurgery |
| Zdroj: | Retinal Degenerative Diseases ISBN: 9783319171203 |
| DOI: | 10.1007/978-3-319-17121-0_59 |
| Popis: | To compare patterns of gene expression following preconditioning cyclic light rearing versus preconditioning aerobic exercise. BALB/C mice were preconditioned either by rearing in 800 lx 12:12 h cyclic light for 8 days or by running on treadmills for 9 days, exposed to toxic levels of light to cause light-induced retinal degeneration (LIRD), then sacrificed and retinal tissue harvested. Subsets of mice were maintained for an additional 2 weeks and for assessment of retinal function by electroretinogram (ERG). Both preconditioning protocols partially but significantly preserved retinal function and morphology and induced similar leukemia inhibitory factor (LIF) gene expression pattern. The data demonstrate that exercise preconditioning and cyclic light preconditioning protect photoreceptors against LIRD and evoke a similar pattern of retinal LIF gene expression. It may be that similar stress response pathways mediate the protection provided by the two preconditioning modalities. |
| Databáze: | OpenAIRE |
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