A traditional herbal formula, Hyangsa-Pyeongwi san (HPS), improves quality of life (QoL) of the patient with functional dyspepsia (FD): Randomized double-blinded controlled trial
| Autor: | Weechang Kang, Dong Soo Lee, Ji-Young Kang, Hye Won Lee, Jang-Woo Shin, Yang-Chun Park, Jeung-Bae Kim, Chang-Gue Son, Jung-Hyo Cho |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Double blinded Traditional Chinese medicine Placebo Total symptom score law.invention Young Adult Double-Blind Method Randomized controlled trial Quality of life law Internal medicine Drug Discovery medicine Humans In patient Dyspepsia Aged Medicine East Asian Traditional Pharmacology Group trial Traditional medicine business.industry Middle Aged Quality of Life Female Plant Preparations business Phytotherapy |
| Zdroj: | Journal of Ethnopharmacology. 151:279-286 |
| ISSN: | 0378-8741 |
| DOI: | 10.1016/j.jep.2013.10.033 |
| Popis: | Ethnopharmacological relevance Hyangaa-Pyeongwi san is the most well known description in Traditional Chinese Medicine for treating functional gastrointestinal disorders. Functional dyspepsia (FD) is a main concern of intimidating quality of life (QoL) in recent days. Although many medicines have been developed to improve FD symptoms as well as QoL, there are no potential drugs and treatments for FD. The aim of this study is to investigate the effects of Hyangaa-Pyeongwi san (HPS) on QoL of patients with FD. Methods This study was designed as a randomized, double blinded, placebo controlled, and parallel group trial. Participants received either placebo or HPS (9.68 g of HPS at once, three times daily) for 4-weeks, and the efficacy evaluations were performed by assessing the Nepean Dyspepsia Index (NDI) and functional dyspepsia-quality of life (FD-QoL) at 0-, 4- and 8-weeks. Results Total of 170 patients participated and were randomly allocated into placebo or HPS groups. Total symptom score of NDI decreased after 4-weeks trial in both groups (p>0.05). HPS significantly improved QoL scores, especially in the area of ‘interference and eat/drink’ in NDI (p=0.0031) as well as ‘liveliness status’, ‘role-functioning status’, and total score in FD-QoL (p=0.026 for liveliness status and p=0.035 for role-functioning status). This significant improvement of FD-QoL had lasted for 4-weeks. Conclusion HPS treatment is markedly effective in improving QoL in patients with FD. Moreover, we observed that this improvement had lasted for 4 weeks after finishing the trial through the follow-up study. |
| Databáze: | OpenAIRE |
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