Dibenzyl bromophenols with diverse dimerization patterns from the brown alga Leathesia nana
| Autor: | Yongchun Yang, Jiangong Shi, Lü Yang, Shuai Li, Jielu Zhao, Suqing Shang, Xiuli Xu, Fuhang Song, Fan Xiao, Sujuan Wang |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
China
Stereochemistry Metabolite Molecular Conformation Pharmaceutical Science Ether Pharmacognosy Crystallography X-Ray Phaeophyta Analytical Chemistry chemistry.chemical_compound Phenols Drug Discovery Tumor Cells Cultured Humans Cytotoxicity Nuclear Magnetic Resonance Biomolecular Pharmacology Bicyclic molecule Molecular Structure Organic Chemistry Acetal Biological activity Stereoisomerism Hydrocarbons Brominated Complementary and alternative medicine chemistry Molecular Medicine Hemiacetal Drug Screening Assays Antitumor Dimerization |
| Zdroj: | Journal of natural products. 67(10) |
| ISSN: | 0163-3864 |
| Popis: | Six novel dibenzyl bromophenols (1-6) with different dimerization patterns and two propyl bromophenol derivatives (7 and 8), together with 11 known bromophenol derivatives, were isolated from the ethanolic extract of the brown alga Leathesia nana. On the basis of spectroscopic methods the structures of the new compounds were determined as 5,6'-diethyloxymethyl-3,4,2'-tribromo-2,3',4'-trihydroxydiphenyl ether (1), 2-(2,3-dibromo-4,5-dihydroxybenzyl)-3,5-dihydroxy-4-methoxybenzyl alcohol (2), 6-(2,3-dibromo-4,5dihydroxybenzyl)-2,3-dibromo-4,5-dihydroxy benzyl methyl ether (3), 9,10-dihydro-9,10-dimethoxy-3,4,7,8-tetrabromo-1,2,5,6-tetrahydroxyanthracene (4), (+)-3-(2,3-dibromo-4,5-dihydroxyphenyl)-4-bromo-5,6-dihydroxy-1,3-dihydroisobenzofuran (5), rel-(4aS*,10aR*)-(+/-)-6,7-dibromo-4a-hydroxy-3,8-dihydroxymethyl-10a-methoxy- 1,4,4a, 10a-tetrahydrodibenzo[b,e][1,4]dioxin-1-one (6), (E)-2-methyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)propenal (7), and 2-methyl-3-(2,3-dibromo-4,5-dihydroxyphenyl)-1-propanol (8). Some compounds including 3 showed in vitro selective cytotoxicity against several human cancer cell lines. This is the first brown alga to be reported containing bromophenols. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|