Serum Copeptin, Pentraxin 3, Anti-Mullerian Hormone Levels With Echocardiography and Carotid Artery Intima-Media Thickness in Adolescents With Polycystic Ovary Syndrome
| Autor: | Eren Akbaba, Özcan Başaran, Mert Küçük, Mehmet Deveer, Ummuhani Ozel Turkcu, Burcu Kasap, Nilgün Öztürk Turhan, Neşat Çullu, Rüya Deveer |
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| Rok vydání: | 2015 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Copeptin Internal medicine medicine.artery AMH PCOS Medicine Common carotid artery PTX3 biology Receiver operating characteristic business.industry Area under the curve Anti-Müllerian hormone General Medicine Polycystic ovary female genital diseases and pregnancy complications Endocrinology Intima-media thickness adolescent biology.protein Original Article business Hormone |
| Zdroj: | Journal of Clinical Medicine Research |
| ISSN: | 1918-3011 1918-3003 |
| Popis: | Background: The aim of the study was to investigate the presence of possible markers in the prediction of polycystic ovary syndrome (PCOS)-related metabolic alterations and cardiovascular events in adolescent PCOS cases and also to investigate the applicability of anti-Mullerian hormone (AMH) levels for the diagnosis of PCOS. Methods: In this cross-sectional study, a total of 75 non-obese women (adolescent PCOS group, n = 25; adult PCOS group, n = 25; control group, n = 25) were included. Measurements of copeptin, pentraxin 3 (PTX3), and AMH serum levels were performed. Results: Serum copeptin, PTX3 and echocardiographic indices were not significantly different in PCOS subjects and they did not have higher common carotid artery intima-media thickness (CIMT) measurement. AMH levels were significantly higher in PCOS patients. There was a positive correlation between AMH and mean ovarian volume (r = 0.58, P < 0.001) and between AMH and total testosterone level (r = 0.63, P < 0.001). In order to predict a threshold value for the diagnosis of PCOS by using AMH, the receiver operating characteristic (ROC) method was used. Area under the curve was 0.820 and cut-off point was 6.66 ng/mL for AMH with a sensitivity of 62% and specificity of 76%. Conclusions: Possible markers for PCOS-related metabolic alterations may not present in the adolescent years. Serum AMH may be useful as a diagnostic test for adolescents. J Clin Med Res. 2015;7(12):989-994 doi: http://dx.doi.org/10.14740/jocmr2375w |
| Databáze: | OpenAIRE |
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